InterMED-Rx

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- P-450 Table

The use of therapeutic regimes that rely on polypharmacy entail higher risks of drug interactions. Consequently, these interactions must be monitored more closely by health professionals.

The InterMED-Rx.ca Website provides health professionals with a user-friendly tool at the cutting edge of scientific knowledge. This site provides a better grasp of drug interactions related to the cytochrome P450 superfamily.

Jacques Turgeon, B.Pharm., Ph.D.

The cytochrome P450 is a superfamily of enzymes whose main role is to transform liposoluble substances into more hydrosoluble substances. This action typically favours the elimination of substances perceived as potentially toxic. It is important to note that the roughly 35 cytochrome P450 isoenzymes found in human beings contribute both to the biotransformation of exogenous and endogenous substances and to the synthesis of endogenous compounds.

In this section of our site, health professionals have access to theoretical notions about the underlying principles of metabolism, the cytochrome P450 superfamily and the particular characteristics of certain isoenzymes. In addition, this section contains theoretical notions about membrane transporters, the P-glycoprotein in particular. These notions make up the basic material of a course (PHM-6508) in the professional continuing education program offered by Université de Montréal’s Faculty of Pharmacy.

In this section of our site, health professionals can enter the complete list of drugs making up a patient’s therapeutic regime. A rapid analysis will identify the substrates of the various P450 isoenzymes as well as the relative affinity of each substrate.

This section of our site provides an original and unique listing of the inhibitors, substrates and inducers of the cytochromes P450 principal isoenzymes. The presentation of substrates in three affinity categories makes it possible to predict which one will lead to a modification of the elimination capacities of another substrate. The selection of a given substrate calls up a list of pre-selected references that provide users with scientific data relevant to their decision.